<pA rocket fired from Gaza struck a residential home in southern Israel<pThe medical service said two other Beersheba residents were injured during the panic to seek cover.
<pThe military said another rocket from Gaza landed in the sea, just off the coast of one of the larger cities in central Israel. No injuries were reported.
<pFollowing the attacks, schools in Beersheba were closed and Israel's military chief was cutting short his visit to the United States to come back and manage the crisis.
<pAs a first response, Israeli military jets pounded Hamas targets across the Gaza Strip. The Gaza Health Ministry said a 25-year-old militant was killed inside one of the posts targeted. Three other people were wounded.
<pLt. Col. Jonathan Conricus, a military spokesman, said 20 Hamas targets were struck, including offensive tunnels, weapon workshops and naval shafts. The military released video purportedly showing militants preparing to fire another rocket toward Israel before they were targeted.
<pThe rocket attack on Beersheba was the first in months and the first that hit an Israeli home there since the 2014 summer war between Israel and Gaza's militant Hamas rulers. Beersheba, which is some 50 kilometers (30 miles) from Gaza, is the biggest city in southern Israel, with a population of around 200,000.
<pIsrael and Hamas have fought three wars over the past decade and fighting has flared up on several occasions recently, though neither side appears to be interested in another full-blown war. Egypt has been trying to mediate a long-term cease-fire.
<pIn a rare move, seemingly aimed at easing the tensions, the "joint coordination room of resistance factions," which includes Hamas, Islamic Jihad and others, issued a statement distancing the groups from the rocket fire.
<p"We reject all irresponsible attempts that try to change the direction and sabotage the Egyptian efforts, including the overnight firing of the rocket," they said. "At the same time, we emphasize we are ready to confront the Israeli aggression."
<pThe head of Egyptian intelligence, Abbas Kamel, was scheduled to visit Gaza this week to renew cease-fire talks. But late Wednesday, Hamas announced his visit had been called off.
<p"We are sorry that minister Abbas Kamel has canceled his visit to Gaza and Ramallah," Moussa Abu Marzouk, a top Hamas official, wrote on Twitter.
<pHowever, a team of other Egyptian security officials was already on its way to try and calm things down.
<pIsraeli Prime Minister Benjamin Netanyahu, meanwhile, held briefings along the Gaza border, vowing that "Israel will act with great force."
<pConricus rejected the militants' statement, saying the rocket that struck Beersheba was a mid-range, locally produced weapon that was in the possession of only two groups: Hamas and Islamic Jihad. Israel holds Hamas responsible for all violence emanating from the territory it controls.
<p"Israel will not stand by while our people are under attack, and the world must know that," Israeli President Reuven Rivlin said as he hosted Nickolay Mladenov, the U.N. Mideast envoy.
<pMladenov, who has been involved in the recent efforts to mediate a truce, said the rocket fire "fit a pattern of provocations that seek to bring Israel and Gaza into another deadly conflict."
<pThe rocket attack came a day after Israeli Defense Minister Avigdor Lieberman said the time had come to deliver a "heavy blow" to Hamas after weeks of escalating violence along the border. Lieberman announced Wednesday that all crossings into Gaza were being shut in response to the attack and the fishing zone around Gaza was being limited.
<pHamas has held weekly border protests for the past six months, aimed in part at easing a crippling Israeli-Egyptian blockade that was put in place after the Islamic militant group violently seized power in 2007. The blockade has restricted Hamas' ability to govern and made life extremely difficult for Gaza's 2 million residents. Electricity is supplied for roughly four hours a day, unemployment stands at more than 50 percent and tap water is undrinkable.
<pThe protests have intensified as Egyptian-mediated cease-fire efforts faltered. Last week, some 14,000 Palestinians thronged to the perimeter fence, burning tires and throwing rocks, firebombs and grenades at soldiers stationed atop earth mounds on the other side. Some 20 Palestinians breached the border during Friday's protest. Seven Palestinians were killed, including four who the military said had entered Israel and approached a military position.
<pIn response, Israel halted Qatari-donated fuel shipments to Gaza's power plant.
<pSince March, 155 Palestinians have been killed during the protests. One Israeli soldier was killed by sniper fire in July.
<pHamas seeks a cease-fire with Israel to secure an easing of the blockade but accuses its West Bank rivals, Fatah, of thwarting the effort. Repeated attempts to reconcile Hamas and the West Bank-based administration of Palestinian President Mahmoud Abbas have failed, adding to the desperation fueling the demonstrations.
<pIn Israel, the fiery threats against Hamas have been coupled with concern over being dragged into an unnecessary escalation that may have more to do with Palestinian infighting.
<pThe limited response has drawn criticism from Israel's typically more dovish opposition
<p"Hamas needs to pay a heavy price," Yair Lapid, head of the centrist Yesh Atid Party, said in front of the damaged house in Beersheba. "What we see here is the result of a government that for nearly five years hasn't decided what its policy is."